TODAY'S SCENE

Studies stir confusion on safety of plastics

By Scott LaFee
Copley News Service


SCOTT LAFEE
PLASTIC SAFETY - Some scientists say animal and cell-culture studies link low-dose BPA exposure to, among other maladies, cancer; other researchers say the findings are inconclusive at best. CNS Photo by Manny Franco.
Marianne Ruegsegger had heard the warnings before.

"I have a friend whose husband is a chemist, and he said never to heat food in plastic, that the molecules can get into the food," Ruegsegger said.

Ruegsegger followed that advice, but continued to use her Tupperware and collection of plastic containers - butter tubs, yogurt cups and the like - for storage and other purposes.

Then came the latest warnings: New scientific studies link bisphenol-a, or BPA, a chemical used in the manufacture of durable plastic bottles, food-can linings and dental fillings, with a host of serious maladies.

Ruegsegger, a computer systems analyst who lives in Escondido, Calif., boxed up her plastic storage tubs and bought glass containers instead.

"I feel safer now, I think," she said.

If Ruegsegger remains a bit uncertain about the real and perceived health hazards posed by plastic - specifically by polycarbonate plastic containing BPA - she is far from alone. For many consumers, the recent flurry of news reports about plastics and health hazards has been conflicting and confusing.

While a growing number of scientists say animal and cell-culture studies link low-dose BPA exposure to everything from altered neural development to reproductive system deformities to cancer, other researchers say the findings are inconclusive at best, irrelevant and fear-mongering at worst.

While Canada reportedly is close to declaring BPA to be a toxic chemical - it would be the first country to do so - the U.S. Food and Drug Administration says there is no compelling proof that BPA harms people.

While the chemical industry adamantly, even aggressively, insists BPA presents no measurable health risk to humans and cites 50 years of safe use, the marketplace appears to be abandoning the chemical. Nalgene, the maker of hugely popular polycarbonate water bottles, has said it will stop using the plastic because of consumer concerns.

Playtex, which makes baby products containing BPA, says it will follow suit. Major retailers including Wal-Mart and Toys "R" Us have announced plans to switch to selling only BPA-free baby bottles, teething rings and other products.

For the consumer, these contradictory actions are both encouraging and alarming. Many experts say it is prudent to reduce, if not avoid, at least some kinds of plastics in some kinds of situations. But in a world dominated by the stuff, how practical is that?

COMPOUND INTEREST

Plastic is everywhere and, it seems, in almost every person. A 2004 survey by the U.S. Centers for Disease Control and Prevention found traces of bisphenol-a in 93 percent of urine samples tested. Japanese scientists say it is detectable in the amniotic fluid and umbilical cords of unborn children.

In April, the National Toxicology Program, part of the federal National Institute of Environmental Health Sciences, issued a draft report highlighting research that showed some lab rats fed or injected with low doses of BPA reached puberty early, had urinary tract problems or developed precancerous tumors.

The agency described the evidence as limited but said the "possibility that bisphenol-a may alter human development cannot be dismissed."

The chemical industry immediately brushed off the report.

"The findings provide reassurance that consumers can continue to use products made from bisphenol-a," said Steven G. Hentges of the American Chemistry Council, an advocacy group.

The draft report marked the first time that a U.S. government agency had expressed public concern about possible health risks posed by BPA.

The final report is not due for a couple of months, pending public and industry response. A call for further research is expected.

Research - or perhaps the lack of it - is at the heart of the conflict and confusion over BPA. The studies suggesting low-dose BPA exposure provokes adverse responses in cells and in test animals number in the hundreds.

The problem is that no one can say with certainty that these findings translate to humans.

"Obviously, this is a situation in which you're never going to directly test people," said Robert Tukey, a professor of chemistry and pharmacology at the University of California San Diego.

Compounding the issue is the question of whether humans are being exposed to hazardous levels of BPA.

"There's no doubt (BPA) can behave as estrogen mimics," said William Trogler, a University of California San Diego chemistry professor. "The issue is the level of exposure, in particular what people actually experience. Is the level significant or not?"

Many studies suggest it is. With improved tools and techniques, researchers are reporting measurable effects from BPA at levels well below those declared safe by government regulators and industry scientists.

Some research indicates humans may be exposed to more BPA than previously thought - that under certain conditions, these chemicals leach out of plastic in higher-than-expected amounts.

For example, a much-reported study this year at the University of Cincinnati found that polycarbonate baby bottles exposed to boiling water - meant to simulate prolonged use and multiple washings - released 55 times more BPA than bottles exposed only to hot water. Other research has shown that old, scratched polycarbonate plastic leaches chemicals more readily than newer material.

The chemical industry counters these reports with other studies citing no significant adverse effect from BPA. Industry spokesmen say the government backs up their position, noting the FDA's announcement last year that it knew of no research compelling enough to merit restricting or banning BPA. In March, FDA officials conceded the conclusion was based on just two industry-funded studies.

To be sure, not every kind of plastic poses a known or suspected health risk. Polyethylene terephthalate ethylene - more commonly known as PET or PETE - is widely used in disposable water, soda and juice bottles. Health experts generally say it poses no known health threat, particularly if it is not re-used.

Likewise, high density polyethylene, or HDPE, plastic, used in milk jugs, shampoo bottles and cleaner containers, is considered to be safe, as is low-density polyethylene, or LDPE, used in bin liners and packaging films, and polypropylene, or PP, used in microwaveable plastics and straws.

More worrisome are polyvinyl chloride, PVC or V, used in cling wrap and some plastic squeeze bottles; polystyrene, used in foam cartons, carryout containers and opaque plastic cutlery; and BPA-laden polycarbonate plastics, used to create rigid, shatter-resistant containers, such as backpacking bottles or baby bottles.

FOREVER PLASTIC

So what's a person to do? Realistically, there probably is no way to avoid exposure to plastics entirely. They are part and parcel of modern American life, found in almost every processed product.

The United States produced 6.5 billion pounds of raw plastic in December 2007, up 2.3 percent from one year earlier.

But if plastic is a permanent fixture of life - decomposition rates range from tens to thousands of years - experts say there are different ways to think about and deal with it.

If a particular plastic poses a health risk, it should be banned, said Sharyle Patton, director of the health and environmental program at Commonweal, a nonprofit research institute in Bolinas, Calif., north of San Francisco.

"I don't want to wait for science to tell me a man-made substance is safe. This can take years," Patton said. "I want these chemicals out of all of our bodies until we know much more about what makes us sick and what keeps us well."

Rick Clark, director of medical toxicology at University of California San Diego Medical Center, said it's not that simple. If the science isn't conclusive, then other factors must be considered.

"My job is to decide whether the risk of a little exposure to a chemical outweighs the benefits of having that chemical," Clark said.

Clark cited the example of benzene, a known human carcinogen that people inhale when they pump gas.

"It's in gasoline because there's no way to get it out 100 percent," he said. "So we take precautions to minimize the health risk, like having those covers on nozzles. The resulting exposure level isn't believed to be high enough to cause leukemia, and we accept the risk because we need the gas."

It's much the same with BPA and other common but possibly hazardous chemicals, Clark said.

"You try to find and use alternative products if you can, but ultimately you have to determine your degree of risk," he said. "I can't tell you that you're not getting an exposure from BPA. I can't tell you for certain the chemical isn't doing something to your body. But the data up to this point is lacking for me.

"I'm not throwing away my Tupperware yet."

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